Welcome to the Searcey Lab
We are a medicinal chemistry and chemical biology research group in the School of Pharmacy at the University of East Anglia, Norwich, UK, interested in targeting DNA and protein-protein interactions.
We are fully equipped for both solid and solution phase peptide and small molecule synthesis. We synthesise molecules inspired by natural products and of a purely synthetic nature to investigate key biological targets for the development of antibiotics and cancer therapeutics.
Our research focuses on the development of novel cancer therapeutics and antibiotics, with a keen interest in targeting DNA and protein-protein interactions.
Current projects include: 1) harnessing the power of the duocarmycins for selective cancer therapeutics; 2) development of peptides and small molecules to stabilise the Holliday junction, a secondary structure of DNA; 3) DNA modifications to stabilise DNA secondary structures; 4) the development of peptides and small molecules as novel antibiotics.
PhD and post-doctoral grants will be advertised here. We always welcome applications to join us, and opportunities to apply for studentships and fellowships are listed here. Feel free to get in touch to discuss current research directions and project ideas.
The Searcey Research Group
School of Pharmacy
University of East Anglia
Norwich Research Park
+44 1603 597544